DOXAPRAM

Search structure
Synonyms:
Status: Approved (1965)
Entry Type: Small molecule
Molecule Category: Parent
ATC: R07AB01
UNII: 94F3830Q73

Structure
InChI Key XFDJYSQDBULQSI-UHFFFAOYSA-N
Smile CCN1CC(CCN2CCOCC2)C(c2ccccc2)(c2ccccc2)C1=O
InChI
InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H30N2O2
Molecular Weight 378.52
AlogP 3.17
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 6.0
Polar Surface Area 32.78
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 28.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Two-pore domain potassium channel
- 16000-37000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Panic Disorder 2 D016584 ClinicalTrials

Related Entries

Salt

Cross References

Resources Reference
CAS NUMBER 309-29-5
ChEBI 681848
ChEMBL CHEMBL1754
DrugBank DB00561
DrugCentral 953
EPA CompTox DTXSID2022963
FDA SRS 94F3830Q73
Human Metabolome Database HMDB0014701
Guide to Pharmacology 7169
PharmGKB PA164784026
PubChem 3156
SureChEMBL SCHEMBL644504
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