ELECLAZINE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: PUY08529FK

Structure
InChI Key YNUAEEJQYHYLMS-UHFFFAOYSA-N
Smile O=C1c2cc(-c3ccc(OC(F)(F)F)cc3)ccc2OCCN1Cc1ncccn1
InChI
InChI=1S/C21H16F3N3O3/c22-21(23,24)30-16-5-2-14(3-6-16)15-4-7-18-17(12-15)20(28)27(10-11-29-18)13-19-25-8-1-9-26-19/h1-9,12H,10-11,13H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H16F3N3O3
Molecular Weight 415.37
AlogP 4.08
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 64.55
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 30.0

Pharmacology

Primary Target
Nav1.5
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 6000 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 100-600 - - 24

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cardiomyopathy, Hypertrophic 2 D002312 ClinicalTrials
Coronary Disease 2 D003327 ClinicalTrials
Arrhythmias, Cardiac 2 D001145 ClinicalTrials
Long QT Syndrome 1 D008133 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 1443211-72-0
ChEMBL CHEMBL3707392
DrugBank DB12394
FDA SRS PUY08529FK
Guide to Pharmacology 8413
PubChem 71183216
SureChEMBL SCHEMBL14480722
ZINC ZINC000206191652
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