EVOGLIPTIN

Search structure


Synonyms:	Da-1229 DA-1229 DA1229 Evogliptin
Status:	Approved
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
ATC:	A10BH07
UNII:	09118300L7

Structure


InChI Key	LCDDAGSJHKEABN-MLGOLLRUSA-N
Smile	CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
InChI	InChI=1S/C19H26F3N3O3/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27)/t12-,16-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H26F3N3O3
Molecular Weight	401.43
AlogP	1.51
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	84.66
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	28.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	Dipeptidyl peptidase IV inhibitor	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease SC clan Serine protease S9B subfamily	-	1	-	-	-
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	79600	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Diabetes Mellitus	3	D003920	ClinicalTrials
Diabetes Mellitus, Type 2	3	D003924	ClinicalTrials
Kidney Diseases	1	D007674	ClinicalTrials
Liver Diseases	1	D008107	ClinicalTrials

Cross References

Resources	Reference
CAS NUMBER	1222102-29-5
ChEMBL	CHEMBL1779710
DrugBank	DB12625
DrugCentral	5239
EPA CompTox	DTXSID00153545
FDA SRS	09118300L7
PDB	8VU
PubChem	25022354
SureChEMBL	SCHEMBL343846
ZINC	ZINC000068267685

CONTENTS