Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: C09CA10
UNII: P58222188P

Structure

InChI Key AMEROGPZOLAFBN-UHFFFAOYSA-N
Smile CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
InChI
InChI=1S/C27H31N7OS/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,29,30,31,32)

Physicochemical Descriptors

Property Name Value
Molecular Formula C27H31N7OS
Molecular Weight 501.66
AlogP 4.22
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 9.0
Polar Surface Area 92.59
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 36.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Type-1 angiotensin II receptor antagonist PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hypertension 3 D006973 ClinicalTrials
Essential Hypertension 3 D000075222 ClinicalTrials
Hyperlipidemias 1 D006949 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 247257-48-3
ChEBI 136044
ChEMBL CHEMBL1951143
DrugBank DB09279
DrugCentral 4906
EPA CompTox DTXSID80179460
FDA SRS P58222188P
PubChem 9870652
SureChEMBL SCHEMBL20126833
ZINC ZINC000003842872