FRUQUINTINIB

Search structure
Synonyms:
Status: Approved (2023)
Entry Type: Small molecule
Molecule Category: Parent
UNII: 49DXG3M5ZW

Structure
InChI Key BALLNEJQLSTPIO-UHFFFAOYSA-N
Smile CNC(=O)c1c(C)oc2cc(Oc3ncnc4cc(OC)c(OC)cc34)ccc12
InChI
InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H19N3O5
Molecular Weight 393.4
AlogP 3.85
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 95.71
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Vascular endothelial growth factor receptor inhibitor PubMed
Primary Target
fms related receptor tyrosine kinase 1
fms related receptor tyrosine kinase 4
kinase insert domain receptor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Stomach Neoplasms 1 D013274 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1194506-26-7
ChEMBL CHEMBL4303214
FDA SRS 49DXG3M5ZW
Guide to Pharmacology 9428
PubChem 44480399
SureChEMBL SCHEMBL947183
ZINC ZINC000114898570
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