GOSOGLIPTIN

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: GI718UO477

Structure
InChI Key QWEWGXUTRTXFRF-KBPBESRZSA-N
Smile O=C([C@@H]1C[C@H](N2CCN(c3ncccn3)CC2)CN1)N1CCC(F)(F)C1
InChI
InChI=1S/C17H24F2N6O/c18-17(19)2-5-25(12-17)15(26)14-10-13(11-22-14)23-6-8-24(9-7-23)16-20-3-1-4-21-16/h1,3-4,13-14,22H,2,5-12H2/t13-,14-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H24F2N6O
Molecular Weight 366.42
AlogP 0.2
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 64.6
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 26.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Dipeptidyl peptidase IV inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Protease Serine protease Serine protease SC clan Serine protease S28 family
- 3300 - - -
Enzyme Protease Serine protease Serine protease SC clan Serine protease S9B subfamily
- 11-13 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- - - - 15

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetes Mellitus, Type 2 3 D003924 ClinicalTrials
Renal Insufficiency, Chronic 1 D051436 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 869490-23-3
ChEMBL CHEMBL515387
DrugBank DB08382
FDA SRS GI718UO477
Guide to Pharmacology 7413
PDB PF2
PubChem 11516136
SureChEMBL SCHEMBL197108
ZINC ZINC000023247686
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