| Synonyms: | |
| Status: | Phase 3 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | QSQ883V35U |
Structure
| InChI Key | TVTXCJFHQKSQQM-LJQIRTBHSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C31H29Cl2F2N3O4 |
| Molecular Weight | 616.49 |
| AlogP | 6.94 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 111.45 |
| Molecular species | ACID |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 42.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Tumour suppressor p53/oncoprotein Mdm2 inhibitor | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Other nuclear protein
|
- | 6-6 | 0 | - | - | |
|
Transcription factor
|
- | 9-10 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Leukemia, Myeloid, Acute | 3 | D015470 | ClinicalTrials |
| Neoplasms | 2 | D009369 | ClinicalTrials |
| Polycythemia Vera | 2 | D011087 | ClinicalTrials |
| Glioblastoma | 1 | D005909 | ClinicalTrials |
| Multiple Myeloma | 1 | D009101 | ClinicalTrials |
| Lymphoma, Follicular | 1 | D008224 | ClinicalTrials |
| Lymphoma, Non-Hodgkin | 1 | D008228 | ClinicalTrials |
| Thrombocythemia, Essential | 1 | D013920 | ClinicalTrials |
| Colorectal Neoplasms | 1 | D015179 | ClinicalTrials |
| Breast Neoplasms | 1 | D001943 | ClinicalTrials |
| Lymphoma, Large B-Cell, Diffuse | 1 | D016403 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1229705-06-9 |
| ChEMBL | CHEMBL2402737 |
| DrugBank | DB12325 |
| FDA SRS | QSQ883V35U |
| PubChem | 53358942 |
| SureChEMBL | SCHEMBL442856 |
| ZINC | ZINC000096273105 |
CONTENTS