JNJ-26483327

Search structure


Synonyms:	JNJ 26483327
Status:	Phase 1
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	16720VER1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H25BrN4O2
Molecular Weight	457.37
AlogP	5.14
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	1.0
Polar Surface Area	59.51
Molecular species	None
Aromatic Rings	3.0
Heavy Atoms	29.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase AKT family	-	-	6	-	-
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase NAK family	-	-	120	-	-
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase SLK subfamily	-	-	45148	-	-
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase RIPK family	-	-	390	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family	-	11	602	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ret family	-	-	2416	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family	-	11	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	11	-	-	-
Enzyme Lyase	-	-	3974	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Neoplasms	1	D009369	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL3545133
FDA SRS	16720VER1H
PubChem	11952856

CONTENTS