| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 2TRH1EX32K |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C35H37N5O6S2 |
| Molecular Weight | 687.84 |
| AlogP | 3.99 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 101.56 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 37.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Insulin-like growth factor I receptor inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
Other protein kinase group
Other protein kinase AUR family
|
- | 66-478 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Breast Neoplasms | 1 | D001943 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545156 |
| FDA SRS | 2TRH1EX32K |
| PubChem | 56847547 |
CONTENTS