| Synonyms: | |
| Status: | Phase 3 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | GMW67QNF9C |
Structure
| InChI Key | ROHFNLRQFUQHCH-YFKPBYRVSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C6H13NO2 |
| Molecular Weight | 131.18 |
| AlogP | 0.44 |
| Hydrogen Bond Acceptor | 2.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 63.32 |
| Molecular species | ZWITTERION |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 9.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC03 and SLC07 families of heteromeric amino acid transporters (HATs)
SLC07 Cationic amino acid transporter/glycoprotein-associated family
|
- | 85000-87000 | - | - | 73-78 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Diabetes Mellitus, Type 2 | 2 | D003924 | ClinicalTrials |
| Red-Cell Aplasia, Pure | 2 | D012010 | ClinicalTrials |
| Depressive Disorder, Major | 2 | D003865 | ClinicalTrials |
| Hyperoxaluria, Primary | 1 | D006960 | ClinicalTrials |
| Sarcopenia | 1 | D055948 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Depressive Disorder | 0 | D003866 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 61-90-5 |
| ChEBI | 57427 |
| ChEMBL | CHEMBL291962 |
| DrugBank | DB00149 |
| DrugCentral | 1557 |
| EPA CompTox | DTXSID9023203 |
| FDA SRS | GMW67QNF9C |
| Human Metabolome Database | HMDB0062203 |
| Guide to Pharmacology | 3312 |
| KEGG | C00123 |
| PDB | LEU |
| PubChem | 6106 |
| SureChEMBL | SCHEMBL3889 |
| ZINC | ZINC000003645145 |
CONTENTS