LICOGLIFLOZIN

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 57J06X6EI0

Structure
InChI Key XFJAMQQAAMJFGB-ZQGJOIPISA-N
Smile CCc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc2c(c1)OCCO2
InChI
InChI=1S/C23H28O7/c1-2-14-4-5-15(23-22(27)21(26)20(25)19(12-24)30-23)11-16(14)9-13-3-6-17-18(10-13)29-8-7-28-17/h3-6,10-11,19-27H,2,7-9,12H2,1H3/t19-,20-,21+,22-,23+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H28O7
Molecular Weight 416.47
AlogP 1.13
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 5.0
Polar Surface Area 108.61
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Sodium/glucose cotransporter 1 inhibitor PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC05 family of sodium-dependent glucose transporters
- 1 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Polycystic Ovary Syndrome 2 D011085 ClinicalTrials
Obesity 2 D009765 ClinicalTrials
Diabetes Mellitus, Type 2 2 D003924 ClinicalTrials
Kidney Diseases 2 D007674 ClinicalTrials
Non-alcoholic Fatty Liver Disease 2 D065626 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 1291094-73-9
ChEMBL CHEMBL4297625
DrugBank DB15048
FDA SRS 57J06X6EI0
Guide to Pharmacology 10654
PubChem 52913524
SureChEMBL SCHEMBL1670083
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