MAPRACORAT

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 145V79YBVP

Structure
InChI Key VJGFOYBQOIPQFY-XMMPIXPASA-N
Smile Cc1ccc2c(NC[C@](O)(CC(C)(C)c3cc(F)cc4c3OCC4)C(F)(F)F)cccc2n1
InChI
InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H26F4N2O2
Molecular Weight 462.49
AlogP 5.69
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 54.38
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 33.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucocorticoid receptor agonist Wikipedia PubMed
Primary Target
Glucocorticoid receptor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cataract 3 D002386 ClinicalTrials
Dermatitis, Atopic 2 D003876 ClinicalTrials
Conjunctivitis, Allergic 2 D003233 ClinicalTrials
Dry Eye Syndromes 2 D015352 ClinicalTrials
Eye Diseases 1 D005128 ClinicalTrials
Psoriasis 1 D011565 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 887375-26-0
ChEMBL CHEMBL2103876
DrugBank DB12041
FDA SRS 145V79YBVP
Guide to Pharmacology 9654
PubChem 24795088
SureChEMBL SCHEMBL1877067
CONTENTS