MEMANTINE

Search structure
Synonyms:
Status: Approved (2003)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N06DX01
UNII: W8O17SJF3T

Structure
InChI Key BUGYDGFZZOZRHP-UHFFFAOYSA-N
Smile CC12CC3CC(C)(C1)CC(N)(C3)C2
InChI
InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H21N
Molecular Weight 179.31
AlogP 2.69
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 0.0
Polar Surface Area 26.02
Molecular species BASE
Aromatic Rings 0.0
Heavy Atoms 13.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 9
Enzyme Protease Aspartic protease Aspartic protease AA clan Aspartic protease A1A subfamily
- - - - 18
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor
- 1090-55400 - 540-1200 41
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- 27200 - - 59

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Dementia 4 D003704 ClinicalTrials
Child Development Disorders, Pervasive 3 D002659 ClinicalTrials
Bipolar Disorder 3 D001714 ClinicalTrials
Schizophrenia 3 D012559 ClinicalTrials
Alzheimer Disease 3 D000544 ClinicalTrials
Pain 3 D010146 ClinicalTrials
Multiple Sclerosis 3 D009103 ClinicalTrials
Fibromyalgia 3 D005356 ClinicalTrials
Anxiety 3 D001007 ClinicalTrials
Glaucoma, Open-Angle 3 D005902 ClinicalTrials
Parkinson Disease 3 D010300 ClinicalTrials
Tension-Type Headache 3 D018781 ClinicalTrials
Substance-Related Disorders 3 D019966 ClinicalTrials
Migraine Disorders 3 D008881 ClinicalTrials
Substance-Related Disorders 3 D019966 ClinicalTrials
Ischemic Stroke 3 D000083242 ClinicalTrials
Depressive Disorder 3 D003866 ClinicalTrials
Obsessive-Compulsive Disorder 2 D009771 ClinicalTrials
Alcoholism 2 D000437 ClinicalTrials
Alcohol Drinking 2 D000428 ClinicalTrials
Opioid-Related Disorders 2 D009293 ClinicalTrials
Neuralgia 2 D009437 ClinicalTrials
Huntington Disease 2 D006816 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Alcoholism 2 D000437 ClinicalTrials
Psychotic Disorders 2 D011618 ClinicalTrials
Heroin Dependence 2 D006556 ClinicalTrials
Psychotic Disorders 2 D011618 ClinicalTrials
Amyotrophic Lateral Sclerosis 2 D000690 ClinicalTrials
Lupus Erythematosus, Systemic 2 D008180 ClinicalTrials
Cognitive Dysfunction 2 D060825 ClinicalTrials
Autistic Disorder 2 D001321 ClinicalTrials
Trichotillomania 2 D014256 ClinicalTrials
Cognitive Dysfunction 2 D060825 ClinicalTrials
Cocaine-Related Disorders 2 D019970 ClinicalTrials
Obesity 1 D009765 ClinicalTrials
Tobacco Use Disorder 1 D014029 ClinicalTrials
Central Nervous System Diseases 1 D002493 ClinicalTrials
Depressive Disorder, Major 1 D003865 ClinicalTrials
Glioma 0 D005910 ClinicalTrials

Related Entries

Salt

Cross References

Resources Reference
CAS NUMBER 19982-08-2
ChEBI 64312
ChEMBL CHEMBL807
DrugBank DB01043
DrugCentral 1679
EPA CompTox DTXSID5045174
FDA SRS W8O17SJF3T
Human Metabolome Database HMDB0015177
Guide to Pharmacology 4253
KEGG C13736
PharmGKB PA10364
PubChem 4054
SureChEMBL SCHEMBL2688
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