MIANSERIN

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: Parent
ATC: N06AX03
UNII: 250PJI13LM

Structure
InChI Key UEQUQVLFIPOEMF-UHFFFAOYSA-N
Smile CN1CCN2c3ccccc3Cc3ccccc3C2C1
InChI
InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H20N2
Molecular Weight 264.37
AlogP 3.08
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 0.0
Polar Surface Area 6.48
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 20.0

Pharmacology

Primary Target
5-HT2A receptor
5-HT2B receptor
5-HT2C receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- 1413-1413 - 252 -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 5500 - - 57
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- 1900 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 407-407 54-2138 28-99 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 3311-3311 - 828-1000 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor
- 0 - 1 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- 11-21 398 1-27 95-98
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Trace amine receptor
- 73000 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 22 - 26-101 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- - - - 48
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 46820 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder 4 D003866 ClinicalTrials
Schizophrenia 3 D012559 ClinicalTrials
Anxiety 3 D001007 ClinicalTrials
Dementia 3 D003704 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 24219-97-4
ChEBI 51137
ChEMBL CHEMBL6437
DrugBank DB06148
DrugCentral 1796
EPA CompTox DTXSID6023317
FDA SRS 250PJI13LM
Human Metabolome Database HMDB0015620
Guide to Pharmacology 135
PharmGKB PA134687937
PubChem 4184
SureChEMBL SCHEMBL18020
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