NAFTOPIDIL

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: R9PHW59SFN

Structure
InChI Key HRRBJVNMSRJFHQ-UHFFFAOYSA-N
Smile COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
InChI
InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H28N2O3
Molecular Weight 392.5
AlogP 3.41
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 7.0
Polar Surface Area 45.17
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Alpha-1d adrenergic receptor antagonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - -
Enzyme Transferase
- - - - 16.68
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -18.88--0.63
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 55.2-55.2 11.75-143.22 3.7-5.888 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hyperplasia 3 D006965 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 57149-07-2
ChEBI 31891
ChEMBL CHEMBL142635
DrugBank DB12092
DrugCentral 1873
EPA CompTox DTXSID5045176
FDA SRS R9PHW59SFN
PubChem 4418
SureChEMBL SCHEMBL113215
CONTENTS