OLMESARTAN

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: Parent
UNII: 8W1IQP3U10

Structure
InChI Key VTRAEEWXHOVJFV-UHFFFAOYSA-N
Smile CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
InChI
InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H26N6O3
Molecular Weight 446.51
AlogP 3.66
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 8.0
Polar Surface Area 129.81
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 33.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Type-1 angiotensin II receptor antagonist PubMed
Primary Target
AT1 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Angiotensin receptor
- 8-8 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hypertension 3 D006973 ClinicalTrials
Atrial Fibrillation 3 D001281 ClinicalTrials
Essential Hypertension 3 D000075222 ClinicalTrials
Stroke 2 D020521 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 144689-24-7
ChEBI 48416
ChEMBL CHEMBL1516
DrugBank DB00275
EPA CompTox DTXSID2040571
FDA SRS 8W1IQP3U10
Human Metabolome Database HMDB0014420
Guide to Pharmacology 591
PDB OLM
PubChem 158781
SureChEMBL SCHEMBL94037
ZINC ZINC000000538621
CONTENTS