PAGOCLONE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 38VAG2SA33

Structure
InChI Key HIUPRQPBWVEQJJ-UHFFFAOYSA-N
Smile CC(C)CCC(=O)CC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1
InChI
InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H22ClN3O2
Molecular Weight 407.9
AlogP 5.38
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 6.0
Polar Surface Area 63.16
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
POSITIVE ALLOSTERIC MODULATOR GABA-A receptor; anion channel positive allosteric modulator PubMed PubMed PubMed

Indications

Mesh Heading Maximum Phase Reference
Stuttering Phase 2 ClinicalTrials
Stuttering Phase 2/Phase 3 ClinicalTrials
Stuttering Phase 2 ClinicalTrials
Premature Birth; Premature Ejaculation Phase 2 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 133737-32-3
ChEMBL CHEMBL2104745
DrugBank DB04903
FDA SRS 38VAG2SA33
PubChem 131664
SureChEMBL SCHEMBL449997
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