PEMAFIBRATE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 17VGG92R23

Structure
InChI Key ZHKNLJLMDFQVHJ-RUZDIDTESA-N
Smile CC[C@@H](Oc1cccc(CN(CCCOc2ccc(OC)cc2)c2nc3ccccc3o2)c1)C(=O)O
InChI
InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)/t25-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C28H30N2O6
Molecular Weight 490.56
AlogP 5.55
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 13.0
Polar Surface Area 94.26
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 36.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Peroxisome proliferator-activated receptor alpha agonist Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 1
1-1 - - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 2
1580-10000 - - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3
1100-1700 - - - -

Indications

Mesh Heading Maximum Phase Reference
Diabetic Retinopathy; Macular Edema; Retinal Diseases Phase 3 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 848259-27-8
ChEMBL CHEMBL247951
DrugBank DB15212
DrugCentral 5248
EPA CompTox DTXSID00233891
FDA SRS 17VGG92R23
PDB P7F
PubChem 11526038
SureChEMBL SCHEMBL2766188
CONTENTS