PF-04217903

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: CYJ9ATV1IJ

Structure
InChI Key PDMUGYOXRHVNMO-UHFFFAOYSA-N
Smile OCCn1cc(-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1
InChI
InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H16N8O
Molecular Weight 372.39
AlogP 1.67
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 107.43
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Hepatocyte growth factor receptor inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9
- 5000 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family
0 4-50 - 5-9400 -
Enzyme Phosphodiesterase Phosphodiesterase 10 Phosphodiesterase 10A
- 2700 - - -
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3A
- 1300 - - 71
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3B
- 1300 - - 71
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4A
- - - - 44
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4B
- - - - 44
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4C
- - - - 44
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D
- - - - 44
Enzyme Phosphodiesterase Phosphodiesterase 5 Phosphodiesterase 5A
- 8060 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- - - - 33

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 1 D009369 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 956905-27-4
ChEBI 91425
ChEMBL CHEMBL2001019
DrugBank DB12848
FDA SRS CYJ9ATV1IJ
PDB KRW
PubChem 17754438
SureChEMBL SCHEMBL93550
ZINC ZINC000043195316
CONTENTS