PF-04937319

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Synonyms:	Pf-04937319
Status:	Phase 1
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	7E99B9ZM19

Structure


InChI Key	MASKQITXHVYVFL-UHFFFAOYSA-N
Smile	Cc1cnc(NC(=O)c2cc(Oc3cnc(C(=O)N(C)C)nc3)c3cc(C)oc3c2)cn1
InChI	InChI=1S/C22H20N6O4/c1-12-8-24-19(11-23-12)27-21(29)14-6-17-16(5-13(2)31-17)18(7-14)32-15-9-25-20(26-10-15)22(30)28(3)4/h5-11H,1-4H3,(H,24,27,29)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H20N6O4
Molecular Weight	432.44
AlogP	3.38
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	123.34
Molecular species	NEUTRAL
Aromatic Rings	4.0
Heavy Atoms	32.0

Pharmacology

Action	Mechanism of Action	Reference
ACTIVATOR	Hexokinase type IV activator	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme	174-1090	-	189	-	-
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	-	-	-	0

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Diabetes Mellitus, Type 2	2	D003924	ClinicalTrials

Cross References

Resources	Reference
CAS NUMBER	1245603-92-2
ChEMBL	CHEMBL2165615
DrugBank	DB15009
FDA SRS	7E99B9ZM19
PDB	S41
PubChem	46916694
SureChEMBL	SCHEMBL1720691
ZINC	ZINC000068246554

CONTENTS