PICLOZOTAN

Search structure


Synonyms:	Piclozotan Sun-n4057 SUN-N-4057
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	FQE44HS7AH

Structure


InChI Key	URMTUEWUIGOJBW-UHFFFAOYSA-N
Smile	O=C1c2ccccc2OC=C(Cl)N1CCCCN1CC=C(c2ccccn2)CC1
InChI	InChI=1S/C23H24ClN3O2/c24-22-17-29-21-9-2-1-7-19(21)23(28)27(22)14-6-5-13-26-15-10-18(11-16-26)20-8-3-4-12-25-20/h1-4,7-10,12,17H,5-6,11,13-16H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H24ClN3O2
Molecular Weight	409.92
AlogP	4.52
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	0.0
Number of Rotational Bond	6.0
Polar Surface Area	45.67
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	29.0

Pharmacology

Action	Mechanism of Action	Reference
AGONIST	Serotonin 1a (5-HT1a) receptor agonist	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	84	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	1	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Stroke	2	D020521	ClinicalTrials
Parkinson Disease	2	D010300	ClinicalTrials

Cross References

Resources	Reference
CAS NUMBER	182415-09-4
ChEMBL	CHEMBL345237
DrugBank	DB12361
FDA SRS	FQE44HS7AH
PubChem	9801640
SureChEMBL	SCHEMBL562627

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