PRITELIVIR

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 07HQ1TJ4JE

Structure
InChI Key IVZKZONQVYTCKC-UHFFFAOYSA-N
Smile Cc1nc(N(C)C(=O)Cc2ccc(-c3ccccn3)cc2)sc1S(N)(=O)=O
InChI
InChI=1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H18N4O3S2
Molecular Weight 402.5
AlogP 2.37
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 106.25
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Helicase/primase inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Lyase
- 2000 - 12.8 -
Enzyme Transferase
- - - - 1.676
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -11.3-23.86
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 160000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Infections 3 D007239 ClinicalTrials
Herpes Genitalis 2 D006558 ClinicalTrials
Herpes Labialis 2 D006560 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 348086-71-5
ChEMBL CHEMBL4069597
DrugBank DB11844
EPA CompTox DTXSID70188344
FDA SRS 07HQ1TJ4JE
PubChem 491941
SureChEMBL SCHEMBL1074614
ZINC ZINC000003955689
CONTENTS