PRUCALOPRIDE

Search structure
Synonyms:
Status: Approved (2018)
Entry Type: Small molecule
Molecule Category: Parent
ATC: A06AX05
UNII: 0A09IUW5TP

Structure
InChI Key ZPMNHBXQOOVQJL-UHFFFAOYSA-N
Smile COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1
InChI
InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H26ClN3O3
Molecular Weight 367.88
AlogP 2.09
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 76.82
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 25.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Serotonin 4 (5-HT4) receptor agonist PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- - - 3981 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
5-26 - - 3-110 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Constipation 4 D003248 ClinicalTrials
Intestinal Pseudo-Obstruction 3 D007418 ClinicalTrials
Deglutition Disorders 2 D003680 ClinicalTrials
Irritable Bowel Syndrome 2 D043183 ClinicalTrials
Ileus 2 D045823 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 179474-81-8
ChEBI 135552
ChEMBL CHEMBL117287
DrugBank DB06480
DrugCentral 3502
EPA CompTox DTXSID5057670
FDA SRS 0A09IUW5TP
Guide to Pharmacology 243
PubChem 3052762
SureChEMBL SCHEMBL16952
ZINC ZINC000001891034
CONTENTS