PRX-08066

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 92E9B7675Y

Structure
InChI Key IENZFHBNCRQMNP-UHFFFAOYSA-N
Smile N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F
InChI
InChI=1S/C19H17ClFN5S/c20-17-8-15-18(23-11-24-19(15)27-17)25-14-3-5-26(6-4-14)10-12-1-2-16(21)13(7-12)9-22/h1-2,7-8,11,14H,3-6,10H2,(H,23,24,25)

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H21ClFN5O4S
Molecular Weight 517.97
AlogP 4.43
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 64.84
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Serotonin 2b (5-HT2b) receptor antagonist PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- 4-270 - 3 -

Indications

Mesh Heading Maximum Phase Reference
Hypertension; Hypertension, Pulmonary Phase 2 ClinicalTrials
Hypertension; Hypertension, Pulmonary; Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive Phase 2 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4297322
DrugBank DB05607
FDA SRS 92E9B7675Y
PubChem 76972919
ChEMBL CHEMBL513994
EPA CompTox DTXSID60235710
FDA SRS 82SK298EBU
PubChem 76972919
SureChEMBL SCHEMBL1604039
ZINC ZINC000040403513
CONTENTS