SOLIFENACIN

Search structure
Synonyms:
Status: Approved (2004)
Entry Type: Small molecule
Molecule Category: Parent
ATC: G04BD08
UNII: A8910SQJ1U

Structure
InChI Key FBOUYBDGKBSUES-VXKWHMMOSA-N
Smile O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1
InChI
InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H26N2O2
Molecular Weight 362.47
AlogP 3.86
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 2.0
Polar Surface Area 32.78
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 27.0

Pharmacology

Primary Target
M2 receptor
M3 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Auxiliary transport protein Slow voltage-gated potassium channel accessory protein family
- 31623 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 251-1585 - - -
Ion channel Voltage-gated ion channel Voltage-gated calcium channel
- 4300 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 6310 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- - - 10 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Urinary Incontinence 4 D014549 ClinicalTrials
Urinary Bladder, Overactive 3 D053201 ClinicalTrials
Prostatic Hyperplasia 3 D011470 ClinicalTrials
Urinary Incontinence, Urge 1 D053202 ClinicalTrials

Related Entries

Scaffolds

UNKNOWN

Cross References

Resources Reference
CAS NUMBER 242478-37-1
ChEBI 135530
ChEMBL CHEMBL1734
DrugBank DB01591
DrugCentral 2457
EPA CompTox DTXSID3048289
FDA SRS A8910SQJ1U
Guide to Pharmacology 7483
PubChem 154059
SureChEMBL SCHEMBL188493
ZINC ZINC000003936683
CONTENTS