SPARSENTAN

Search structure
Synonyms:
Status: Approved (2023)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 9242RO5URM

Structure
InChI Key WRFHGDPIDHPWIQ-UHFFFAOYSA-N
Smile CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2noc(C)c2C)c(COCC)c1
InChI
InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)

Physicochemical Descriptors

Property Name Value
Molecular Formula C32H40N4O5S
Molecular Weight 592.76
AlogP 6.54
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 12.0
Polar Surface Area 114.1
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 42.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Endothelin receptor ET-A antagonist PubMed Other Other
Primary Target
AT1 receptor
ETA receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Angiotensin receptor
- - - 1-1 -
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Endothelin receptor
- - - 9-9 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Glomerulosclerosis, Focal Segmental 3 D005923 ClinicalTrials
Glomerulonephritis, IGA 3 D005922 ClinicalTrials
Hypertension 2 D006973 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 254740-64-2
ChEMBL CHEMBL539423
DrugBank DB12548
FDA SRS 9242RO5URM
Guide to Pharmacology 8448
PubChem 10257882
SureChEMBL SCHEMBL535109
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