SUMANIROLE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 3E93IV1U45

Structure
InChI Key RKZSNTNMEFVBDT-MRVPVSSYSA-N
Smile CN[C@@H]1Cc2cccc3[nH]c(=O)n(c23)C1
InChI
InChI=1S/C11H13N3O/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9/h2-4,8,12H,5-6H2,1H3,(H,13,15)/t8-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H13N3O
Molecular Weight 203.25
AlogP 0.47
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 49.82
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 15.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Dopamine D2 receptor agonist PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
5-543 - - 546-6330 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- - - 73 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Parkinson Disease 3 D010300 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 179386-43-7
ChEMBL CHEMBL419792
DrugBank DB06477
FDA SRS 3E93IV1U45
Guide to Pharmacology 3949
PubChem 9818479
SureChEMBL SCHEMBL154412
ZINC ZINC000003960633
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