SURUFATINIB

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: B2K5L1L8S9

Structure
InChI Key TTZSNFLLYPYKIL-UHFFFAOYSA-N
Smile Cc1cc2cc(Oc3ccnc(Nc4cccc(CS(=O)(=O)NCCN(C)C)c4)n3)ccc2[nH]1
InChI
InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H28N6O3S
Molecular Weight 480.59
AlogP 3.78
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 10.0
Polar Surface Area 112.24
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 34.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Fibroblast growth factor receptor 1 inhibitor Other ClinicalTrials Other

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neuroendocrine Tumors 3 D018358 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1308672-74-3
ChEMBL CHEMBL4297190
DrugBank DB15106
FDA SRS B2K5L1L8S9
Guide to Pharmacology 9769
PubChem 52920501
SureChEMBL SCHEMBL1822601
ZINC ZINC000117218067
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