TASELISIB

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: L08J2O299M

Structure
InChI Key BEUQXVWXFDOSAQ-UHFFFAOYSA-N
Smile Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1
InChI
InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H28N8O2
Molecular Weight 460.54
AlogP 3.17
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 118.67
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 34.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR PI3-kinase class I inhibitor PubMed DOI Other
Primary Target
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family Atypical protein kinase FRAP subfamily
- - - 1200 -
Enzyme Transferase
- 4-31 - 0-0 70

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Breast Neoplasms 3 D001943 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 1282512-48-4
ChEMBL CHEMBL2387080
DrugBank DB12108
EPA CompTox DTXSID00155842
FDA SRS L08J2O299M
Guide to Pharmacology 7794
PDB 799
PharmGKB PA166163227
PubChem 51001932
SureChEMBL SCHEMBL1485247
ZINC ZINC000068267049
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