| Synonyms: | |
| Status: | Approved (2017) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN Prodrug |
| UNII: | 8G388563M7 |
Structure
| InChI Key | MDSQOJYHHZBZKA-GBXCKJPGSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C27H26ClF3N6O3 |
| Molecular Weight | 574.99 |
| AlogP | 4.99 |
| Hydrogen Bond Acceptor | 9.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 9.0 |
| Polar Surface Area | 131.17 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 40.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Tryptophan 5-hydroxylase inhibitor | FDA |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Carcinoid Heart Disease | 3 | D002275 | ClinicalTrials |
| Neuroendocrine Tumors | 3 | D018358 | ClinicalTrials |
| Malignant Carcinoid Syndrome | 2 | D008303 | ClinicalTrials |
| Biliary Tract Neoplasms | 2 | D001661 | ClinicalTrials |
| Liver Diseases | 1 | D008107 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1033805-22-9 |
| ChEMBL | CHEMBL2105695 |
| DrugBank | DB12095 |
| DrugCentral | 5214 |
| FDA SRS | 8G388563M7 |
| Guide to Pharmacology | 9490 |
| PubChem | 25181577 |
| SureChEMBL | SCHEMBL610588 |
| ZINC | ZINC000043205655 |
CONTENTS