TEZACITABINE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: UCC4EQS7WL

Structure
InChI Key GFFXZLZWLOBBLO-ASKVSEFXSA-N
Smile Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)/C2=C\F)c(=O)n1
InChI
InChI=1S/C10H12FN3O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-3,6,8-9,15-16H,4H2,(H2,12,13,17)/b5-3+/t6-,8+,9-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H12FN3O4
Molecular Weight 257.22
AlogP -1.07
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 2.0
Polar Surface Area 110.6
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Ribonucleoside-diphosphate reductase RR1 inhibitor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Adenocarcinoma 2 D000230 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 171176-43-5
ChEMBL CHEMBL3989496
EPA CompTox DTXSID00169020
FDA SRS UCC4EQS7WL
PubChem 6435808
SureChEMBL SCHEMBL18724
CAS NUMBER 171176-43-5
ChEMBL CHEMBL2105467
DrugBank DB06433
EPA CompTox DTXSID10156446
FDA SRS UCC4EQS7WL
PubChem 6435808
SureChEMBL SCHEMBL18724
ZINC ZINC000003777826
CONTENTS