TOFOGLIFLOZIN

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 554245W62T

Structure
InChI Key VWVKUNOPTJGDOB-BDHVOXNPSA-N
Smile CCc1ccc(Cc2ccc3c(c2)[C@]2(OC3)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
InChI
InChI=1S/C22H26O6/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22/h3-8,10,18-21,23-26H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H26O6
Molecular Weight 386.44
AlogP 1.0
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 4.0
Polar Surface Area 99.38
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Sodium/glucose cotransporter 2 inhibitor PubMed
Primary Target
Sodium/glucose cotransporter 2
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC05 family of sodium-dependent glucose transporters
- 3-4 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetes Mellitus, Type 2 2 D003924 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 903565-83-3
ChEBI 136041
ChEMBL CHEMBL2110731
DrugBank DB11824
DrugCentral 4892
EPA CompTox DTXSID90238097
FDA SRS 554245W62T
Guide to Pharmacology 9395
PubChem 46908928
SureChEMBL SCHEMBL903156
ZINC ZINC000035826342
CAS NUMBER 903565-83-3
ChEMBL CHEMBL2105711
EPA CompTox DTXSID70152722
FDA SRS P8DD8KX4O4
Guide to Pharmacology 9395
PubChem 46908928
SureChEMBL SCHEMBL19328161
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