TRANYLCYPROMINE

Search structure
Synonyms:
Status: Approved (1961)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N06AF04
UNII: 3E3V44J4Z9

Structure
InChI Key AELCINSCMGFISI-UHFFFAOYSA-N
Smile NC1CC1c1ccccc1
InChI
InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H22N2
Molecular Weight 266.39
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Primary Target
Monoamine oxidase A
Monoamine oxidase B
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2A Cytochrome P450 2A6
- - 2000 130 -
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2A
- - 2000 130 -
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2B Cytochrome P450 2B6
- 6240-6960 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C19
- 1900-10300 - - -
Enzyme Oxidoreductase
- 250-20000 - 26 -
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily
- - - 13300 -
Epigenetic regulator Eraser Lysine demethylase Lysine-specific demethylase
- 11600-39660 - 21000-25000 18-18
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- - - 12793 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
2697 - - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - -
Unclassified protein
- 8800-30600 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder 4 D003866 ClinicalTrials
Dementia 3 D003704 ClinicalTrials
Anxiety 3 D001007 ClinicalTrials
Schizophrenia 3 D012559 ClinicalTrials
Myelodysplastic Syndromes 1 D009190 ClinicalTrials
Hypotension, Orthostatic 1 D007024 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Depressive Disorder, Major 1 D003865 ClinicalTrials

Related Entries

UNKNOWN

Cross References

Resources Reference
CAS NUMBER 155-09-9
ChEMBL CHEMBL3989843
FDA SRS 3E3V44J4Z9
Guide to Pharmacology 5281
PubChem 19493
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