VADADUSTAT

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: I60W9520VV

Structure
InChI Key JGRXMPYUTJLTKT-UHFFFAOYSA-N
Smile O=C(O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O
InChI
InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H11ClN2O4
Molecular Weight 306.71
AlogP 1.92
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 99.52
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Egl nine homolog 1 inhibitor Other PubMed PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Oxidoreductase
- 29-13700 - 280 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Anemia 3 D000740 ClinicalTrials
Renal Insufficiency, Chronic 2 D051436 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 1000025-07-9
ChEMBL CHEMBL3646221
DrugBank DB12255
FDA SRS I60W9520VV
PDB A1Z
PubChem 23634441
SureChEMBL SCHEMBL1920738
ZINC ZINC000117532869
CONTENTS