VINDESINE

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: Parent
ATC: L01CA03
UNII: RSA8KO39WH

Structure
InChI Key HHJUWIANJFBDHT-KOTLKJBCSA-N
Smile CC[C@]1(O)C[C@H]2C[N@](CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1
InChI
InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C43H55N5O7
Molecular Weight 753.94
AlogP 2.73
Hydrogen Bond Acceptor 10.0
Hydrogen Bond Donor 5.0
Number of Rotational Bond 6.0
Polar Surface Area 164.82
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 55.0

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Leukemia-Lymphoma, Adult T-Cell 3 D015459 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Leukemia 3 D007938 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Neuroblastoma 3 D009447 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 D054198 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 D054198 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Lymphoma, T-Cell, Peripheral 2 D016411 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials

Related Entries

MCS

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 53643-48-4
ChEMBL CHEMBL238071
DrugBank DB00309
DrugCentral 2826
FDA SRS RSA8KO39WH
PubChem 11643449
SureChEMBL SCHEMBL13524311
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