ANLOTINIB

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: Parent
UNII: GKF8S4C432

Structure
InChI Key KSMZEXLVHXZPEF-UHFFFAOYSA-N
Smile COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ccnc2cc1OCC1(N)CC1
InChI
InChI=1S/C23H22FN3O3/c1-13-9-15-16(27-13)3-4-19(22(15)24)30-18-5-8-26-17-11-21(20(28-2)10-14(17)18)29-12-23(25)6-7-23/h3-5,8-11,27H,6-7,12,25H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H22FN3O3
Molecular Weight 407.45
AlogP 4.83
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 82.39
Molecular species BASE
Aromatic Rings 4.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Platelet-derived growth factor receptor beta inhibitor ClinicalTrials Other

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Small Cell Lung Carcinoma 3 D055752 ClinicalTrials
Neoplasms 3 D009369 ClinicalTrials
Neoplasms 3 D009369 ClinicalTrials
Sarcoma, Alveolar Soft Part 3 D018234 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Leiomyosarcoma 3 D007890 ClinicalTrials
Sarcoma, Synovial 3 D013584 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Histiocytoma, Malignant Fibrous 2 D051677 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Brain Stem Neoplasms 2 D020295 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Bone Neoplasms 2 D001859 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Neuroblastoma 2 D009447 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Triple Negative Breast Neoplasms 2 D064726 ClinicalTrials
Carcinoma, Renal Cell 2 D002292 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Carcinoma, Medullary 2 D018276 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Cholangiocarcinoma 1 D018281 ClinicalTrials
Uterine Cervical Neoplasms 1 D002583 ClinicalTrials
Pancreatic Neoplasms 1 D010190 ClinicalTrials
Sarcoma, Ewing 1 D012512 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 1058156-90-3
ChEMBL CHEMBL4303201
FDA SRS GKF8S4C432
Guide to Pharmacology 9601
SureChEMBL SCHEMBL2063386
ZINC ZINC000117924202
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