| Synonyms: | |
| Status: | Approved (1998) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | G04BE03 |
| UNII: | 3M7OB98Y7H |
Structure
| InChI Key | BNRNXUUZRGQAQC-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H30N6O4S |
| Molecular Weight | 474.59 |
| AlogP | 1.61 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 113.42 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 33.0 |
Pharmacology
| Primary Target | |
|---|---|
| phosphodiesterase 5A |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Erectile Dysfunction | 4 | D007172 | ClinicalTrials |
| Erectile Dysfunction | 4 | D007172 | ClinicalTrials |
| Hypertension | 3 | D006973 | ClinicalTrials |
| Scleroderma, Systemic | 3 | D012595 | ClinicalTrials |
| Glaucoma | 3 | D005901 | ClinicalTrials |
| Idiopathic Pulmonary Fibrosis | 3 | D054990 | ClinicalTrials |
| Heart Failure | 3 | D006333 | ClinicalTrials |
| Diabetes Mellitus | 3 | D003920 | ClinicalTrials |
| Hypertension, Pulmonary | 3 | D006976 | ClinicalTrials |
| Persistent Fetal Circulation Syndrome | 3 | D010547 | ClinicalTrials |
| Coronary Vasospasm | 3 | D003329 | ClinicalTrials |
| Peripheral Arterial Disease | 3 | D058729 | ClinicalTrials |
| Heart Failure | 3 | D006333 | ClinicalTrials |
| Hypertension, Pulmonary | 3 | D006976 | ClinicalTrials |
| Eisenmenger Complex | 3 | D004541 | ClinicalTrials |
| Lung Diseases | 3 | D008171 | ClinicalTrials |
| Arterial Occlusive Diseases | 3 | D001157 | ClinicalTrials |
| Bronchopulmonary Dysplasia | 2 | D001997 | ClinicalTrials |
| Sexual Dysfunction, Physiological | 2 | D012735 | ClinicalTrials |
| Cystic Fibrosis | 2 | D003550 | ClinicalTrials |
| Prostatic Hyperplasia | 2 | D011470 | ClinicalTrials |
| Fetal Growth Retardation | 2 | D005317 | ClinicalTrials |
| Premature Birth | 2 | D047928 | ClinicalTrials |
| Parkinson Disease | 2 | D010300 | ClinicalTrials |
| Muscular Dystrophy, Duchenne | 2 | D020388 | ClinicalTrials |
| Infertility | 2 | D007246 | ClinicalTrials |
| Raynaud Disease | 2 | D011928 | ClinicalTrials |
| Pre-Eclampsia | 2 | D011225 | ClinicalTrials |
| Carcinoma, Non-Small-Cell Lung | 2 | D002289 | ClinicalTrials |
| Skin Ulcer | 2 | D012883 | ClinicalTrials |
| Muscular Dystrophy, Duchenne | 2 | D020388 | ClinicalTrials |
| Cerebral Small Vessel Diseases | 2 | D059345 | ClinicalTrials |
| Priapism | 2 | D011317 | ClinicalTrials |
| Brain Injuries | 2 | D001930 | ClinicalTrials |
| Pregnancy | 2 | D011247 | ClinicalTrials |
| Scleroderma, Localized | 2 | D012594 | ClinicalTrials |
| Hypoplastic Left Heart Syndrome | 2 | D018636 | ClinicalTrials |
| Severe Acute Respiratory Syndrome | 1 | D045169 | ClinicalTrials |
| Coronary Disease | 1 | D003327 | ClinicalTrials |
| Infertility, Female | 1 | D007247 | ClinicalTrials |
| Liver Cirrhosis | 1 | D008103 | ClinicalTrials |
| Acute Kidney Injury | 1 | D058186 | ClinicalTrials |
| Mycobacterium Infections | 1 | D009164 | ClinicalTrials |
| Urinary Incontinence | 1 | D014549 | ClinicalTrials |
| Heart Diseases | 1 | D006331 | ClinicalTrials |
| Myelodysplastic Syndromes | 1 | D009190 | ClinicalTrials |
| Anemia, Sickle Cell | 1 | D000755 | ClinicalTrials |
| Brain Diseases | 1 | D001927 | ClinicalTrials |
| Ischemic Stroke | 1 | D000083242 | ClinicalTrials |
| Lymphangioma | 1 | D008202 | ClinicalTrials |
| Pulmonary Embolism | 1 | D011655 | ClinicalTrials |
| Hepatitis C | 1 | D006526 | ClinicalTrials |
| Migraine with Aura | 0 | D020325 | ClinicalTrials |
| Pulmonary Edema | 0 | D011654 | ClinicalTrials |
| Foramen Ovale, Patent | 0 | D054092 | ClinicalTrials |
| Skin Diseases | 0 | D012871 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 139755-83-2 |
| ChEBI | 9139 |
| ChEMBL | CHEMBL192 |
| DrugBank | DB00203 |
| DrugCentral | 2441 |
| EPA CompTox | DTXSID6023579 |
| FDA SRS | 3M7OB98Y7H |
| Human Metabolome Database | HMDB0005039 |
| Guide to Pharmacology | 4743 |
| KEGG | C07259 |
| PDB | VIA |
| PharmGKB | PA451346 |
| PubChem | 135398744 |
| SureChEMBL | SCHEMBL1895 |
| ZINC | ZINC000019796168 |
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