Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: B9Z1OEH19D

Structure

InChI Key NVWCZRPXYVDQEE-UHFFFAOYSA-N
Smile CCCNC(=O)c1nnc2c(-c3cc(OC)ccc3OC)cccc2c1N
InChI
InChI=1S/C20H22N4O3/c1-4-10-22-20(25)19-17(21)14-7-5-6-13(18(14)23-24-19)15-11-12(26-2)8-9-16(15)27-3/h5-9,11H,4,10H2,1-3H3,(H2,21,23)(H,22,25)

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H22N4O3
Molecular Weight 366.42
AlogP 3.04
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 99.36
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
POSITIVE ALLOSTERIC MODULATOR GABA receptor alpha-2 subunit positive allosteric modulator PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel GABA-A receptor
- - - 5-15 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Anxiety 1 D001007 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL1783256
DrugBank DB12210
FDA SRS B9Z1OEH19D
SureChEMBL SCHEMBL1962946
ZINC ZINC000071295757