Synonyms: | |
Status: | Phase 1 |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
UNII: | B9Z1OEH19D |
InChI Key | NVWCZRPXYVDQEE-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C20H22N4O3 |
Molecular Weight | 366.42 |
AlogP | 3.04 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 6.0 |
Polar Surface Area | 99.36 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 27.0 |
Action | Mechanism of Action | Reference |
---|---|---|
POSITIVE ALLOSTERIC MODULATOR | GABA receptor alpha-2 subunit positive allosteric modulator | PubMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Ion channel
Ligand-gated ion channel
GABA-A receptor
|
- | - | - | 5-15 | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Anxiety | 1 | D001007 | ClinicalTrials |
Resources | Reference |
---|---|
ChEMBL | CHEMBL1783256 |
DrugBank | DB12210 |
FDA SRS | B9Z1OEH19D |
SureChEMBL | SCHEMBL1962946 |
ZINC | ZINC000071295757 |