AZD0328

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 2B218X5QIY

Structure
InChI Key OCKIPDMKGPYYJS-ZDUSSCGKSA-N
Smile c1cnc2c(c1)C[C@@]1(CN3CCC1CC3)O2
InChI
InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H16N2O
Molecular Weight 216.28
AlogP 1.48
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 0.0
Polar Surface Area 25.36
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 16.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Neuronal acetylcholine receptor protein alpha-7 subunit agonist PubMed PubMed
Primary Target
nicotinic acetylcholine receptor α7 subunit
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- - - 12 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor alpha subunit
340 - - 3-3 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor beta subunit
- - - 140 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Schizophrenia 2 D012559 ClinicalTrials
Alzheimer Disease 1 D000544 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL2151437
DrugBank DB12145
FDA SRS 2B218X5QIY
Guide to Pharmacology 7697
SureChEMBL SCHEMBL1459640
ZINC ZINC000033961869
CONTENTS