TENOFOVIR DISOPROXIL

Search structure
Synonyms:
Status: Approved (2001)
Entry Type: Small molecule
Molecule Category: Parent Prodrug
ATC: J05AF07
UNII: F4YU4LON7I

Structure
InChI Key JFVZFKDSXNQEJW-CQSZACIVSA-N
Smile CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C
InChI
InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H30N5O10P
Molecular Weight 519.45
AlogP 3.04
Hydrogen Bond Acceptor 15.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 13.0
Polar Surface Area 185.44
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 35.0

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Hepatitis C, Chronic 2 D019698 ClinicalTrials
Hepatitis D 2 D003699 ClinicalTrials
Hepatitis B, Chronic 2 D019694 ClinicalTrials
HIV Infections 2 D015658 ClinicalTrials
Hepatitis B, Chronic 2 D019694 ClinicalTrials
Liver Cirrhosis, Biliary 2 D008105 ClinicalTrials
Hepatitis 1 D006505 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 201341-05-1
ChEBI 63717
ChEMBL CHEMBL1538
DrugBank DB00300
DrugCentral 2593
EPA CompTox DTXSID5052757
FDA SRS F4YU4LON7I
PubChem 5481350
SureChEMBL SCHEMBL52793
ZINC ZINC000003929022
CONTENTS