| Synonyms: | |
| Status: | Approved |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| ATC: | G04BE11 |
| UNII: | L5IB4XLY36 |
Structure
| InChI Key | IYFNEFQTYQPVOC-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C25H36N6O4S |
| Molecular Weight | 516.67 |
| AlogP | 2.83 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 11.0 |
| Polar Surface Area | 122.21 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 36.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Phosphodiesterase 5A inhibitor | PubMed |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Erectile Dysfunction | 3 | D007172 | ClinicalTrials |
| Hypertension, Pulmonary | 3 | D006976 | ClinicalTrials |
| Heart Failure, Diastolic | 3 | D054144 | ClinicalTrials |
| Heart Diseases | 3 | D006331 | ClinicalTrials |
| Alzheimer Disease | 3 | D000544 | ClinicalTrials |
| Heart Failure, Systolic | 3 | D054143 | ClinicalTrials |
| Dementia, Vascular | 2 | D015140 | ClinicalTrials |
| Raynaud Disease | 2 | D011928 | ClinicalTrials |
| Liver Diseases | 1 | D008107 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 268203-93-6 |
| ChEBI | 135926 |
| ChEMBL | CHEMBL2103849 |
| DrugBank | DB06267 |
| DrugCentral | 4141 |
| FDA SRS | L5IB4XLY36 |
| Human Metabolome Database | HMDB0015628 |
| PharmGKB | PA164776753 |
| PubChem | 135413547 |
| SureChEMBL | SCHEMBL120993 |
CONTENTS