UDENAFIL

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: G04BE11
UNII: L5IB4XLY36

Structure
InChI Key IYFNEFQTYQPVOC-UHFFFAOYSA-N
Smile CCCOc1ccc(S(=O)(=O)NCCC2CCCN2C)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1
InChI
InChI=1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32)

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H36N6O4S
Molecular Weight 516.67
AlogP 2.83
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 11.0
Polar Surface Area 122.21
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 36.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Phosphodiesterase 5A inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 5 Phosphodiesterase 5A
- 8.25 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hypertension, Pulmonary 3 D006976 ClinicalTrials
Heart Failure, Diastolic 3 D054144 ClinicalTrials
Heart Diseases 3 D006331 ClinicalTrials
Heart Failure, Systolic 3 D054143 ClinicalTrials
Alzheimer Disease 3 D000544 ClinicalTrials
Raynaud Disease 2 D011928 ClinicalTrials
Dementia, Vascular 2 D015140 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 268203-93-6
ChEBI 135926
ChEMBL CHEMBL2103849
DrugBank DB06267
DrugCentral 4141
FDA SRS L5IB4XLY36
Human Metabolome Database HMDB15628
PharmGKB PA164776753
PubChem 6918523
SureChEMBL SCHEMBL120993
CONTENTS