BENAZEPRIL

Search structure
Synonyms:
Status: Approved (1991)
Entry Type: Small molecule
Molecule Category: Parent Prodrug
ATC: C09AA07
UNII: UDM7Q7QWP8

Structure
InChI Key XPCFTKFZXHTYIP-PMACEKPBSA-N
Smile CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O
InChI
InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H28N2O5
Molecular Weight 424.5
AlogP 2.57
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 9.0
Polar Surface Area 95.94
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 31.0

Pharmacology

Primary Target
Angiotensin-converting enzyme
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Protease Metallo protease Metallo protease MAE clan Metallo protease M2 family
- 2-212 - - 16-100

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetes Mellitus 3 D003920 ClinicalTrials
Hypertension 3 D006973 ClinicalTrials
Diabetes Mellitus, Type 2 3 D003924 ClinicalTrials
Hypercholesterolemia 3 D006937 ClinicalTrials
Coronary Disease 3 D003327 ClinicalTrials
Atherosclerosis 3 D050197 ClinicalTrials
Nephritis, Hereditary 2 D009394 ClinicalTrials
Lupus Erythematosus, Systemic 2 D008180 ClinicalTrials

Related Entries

Scaffolds

UNKNOWN

Cross References

Resources Reference
CAS NUMBER 86541-75-5
ChEBI 3011
ChEMBL CHEMBL838
DrugBank DB00542
DrugCentral 299
EPA CompTox DTXSID5022645
FDA SRS UDM7Q7QWP8
Human Metabolome Database HMDB0014682
Guide to Pharmacology 6374
KEGG C06843
PharmGKB PA448561
PubChem 5362124
SureChEMBL SCHEMBL16396
ZINC ZINC000003781943
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