PF-06651600

Search structure


Status:	Phase 3
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	2OYE00PC25

Structure


InChI Key	CBRJPFGIXUFMTM-WDEREUQCSA-N
Smile	C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C
InChI	InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H19N5O
Molecular Weight	285.35
AlogP	1.94
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	73.91
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	21.0

Indications

Mesh Heading	Maximum Phase	Reference
Alopecia; Alopecia Areata	Phase 2	ClinicalTrials
Colitis; Colitis, Ulcerative; Ulcer	Phase 2	ClinicalTrials
Renal Insufficiency	Phase 1	ClinicalTrials
Alopecia; Alopecia Areata	Phase 3	ClinicalTrials
Arthritis; Arthritis, Rheumatoid	Phase 2	ClinicalTrials
Vitiligo	Phase 2	ClinicalTrials
Crohn Disease	Phase 2	ClinicalTrials

Cross References

Resources	Reference
CAS NUMBER	1792180-81-4
ChEMBL	CHEMBL4085457
DrugBank	DB14924
FDA SRS	2OYE00PC25
Guide to Pharmacology	9559
SureChEMBL	SCHEMBL16764638
ZINC	ZINC000526061581

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