FLUDARABINE

Search structure
Status: Approved
Entry Type: Small molecule
Molecule Category: Parent
ATC: L01BB05

Structure
InChI Key HBUBKKRHXORPQB-FJFJXFQQSA-N
Smile Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1

Experimental and Estimated Properties

Property Name Value Unit Method
log P (octanol-water) -1.180 - EST
Henry's Law Constant 1.30E-22 atm-m3/mole EST
Atmospheric OH Rate Constant 2.38E-10 cm3/molecule-sec EST
Melting Point 260 deg C EXP
Water Solubility 3530 mg/L EST
Vapor Pressure 3.70E-15 mm Hg EST

Pharmacology

Primary Target
ribonucleotide reductase catalytic subunit M1
ribonucleotide reductase regulatory subunit M2

Indications

Mesh Heading Maximum Phase Reference
Leukemia, Plasma Cell; Multiple Myeloma; Neoplasms, Plasma Cell Phase 2 ClinicalTrials
Immunologic Deficiency Syndromes Phase 2 ClinicalTrials
Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute Phase 2/Phase 3 ClinicalTrials
Immunologic Deficiency Syndromes Phase 2 ClinicalTrials

Related Entries

Scaffolds

Salt
UNKNOWN
CONTENTS