| Synonyms: | |
| Status: | Approved |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 6GQP90I798 |
Structure
| InChI Key | SUPKOOSCJHTBAH-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C8H12N5O4P |
| Molecular Weight | 273.19 |
| AlogP | -0.44 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 136.38 |
| Molecular species | ACID |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 18.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | DNA polymerase/reverse transcriptase inhibitor | FDA |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Structural protein
|
83 | - | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Hepatitis B, Chronic | 3 | D019694 | ClinicalTrials |
| Hepatitis B, Chronic | 3 | D019694 | ClinicalTrials |
| HIV Infections | 1 | D015658 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 106941-25-7 |
| ChEBI | 2469 |
| ChEMBL | CHEMBL484 |
| DrugBank | DB13868 |
| EPA CompTox | DTXSID6046214 |
| FDA SRS | 6GQP90I798 |
| KEGG | C11277 |
| PDB | 5HG |
| PubChem | 60172 |
| SureChEMBL | SCHEMBL49373 |
| ZINC | ZINC000021297308 |
CONTENTS