| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | M964LB1114 |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C27H24F5N5O3 |
| Molecular Weight | 561.51 |
| AlogP | 6.04 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 9.0 |
| Polar Surface Area | 89.78 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 40.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Dual specificity protein kinase TTK inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Hydrolase
|
- | - | - | - | 0.3031 | |
|
Enzyme
Kinase
Protein Kinase
Other protein kinase group
Other protein kinase TTK family
|
- | 0.25-121.1 | - | - | - | |
|
Enzyme
|
- | 0.25-121.1 | - | - | 0.3031 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 1 | D009369 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3544955 |
| FDA SRS | M964LB1114 |
| PubChem | 78320750 |
CONTENTS