SULFAMETHAZINE

Search structure
Synonyms:
Status: Approved (1949)
Entry Type: Small molecule
Molecule Category: Parent
UNII: 48U51W007F

Structure
InChI Key ASWVTGNCAZCNNR-UHFFFAOYSA-N
Smile Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
InChI
InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H14N4O2S
Molecular Weight 278.34
AlogP 1.48
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 97.97
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 19.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bacterial dihydropteroate synthase inhibitor ISBN PubMed PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9
- - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 91

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 102265
ChEMBL CHEMBL446
DrugBank DB01582
DrugCentral 2502
EPA CompTox DTXSID6021290
FDA SRS 48U51W007F
Human Metabolome Database HMDB0015522
KEGG C19530
PharmGKB PA451542
PubChem 5327
SureChEMBL SCHEMBL151305
ZINC ZINC000000057494
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