| Synonyms: | |
| Status: | Phase 3 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | FU8XW5V3FS |
Structure
| InChI Key | KYJWUPZPSXZEPG-NTISSMGPSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C38H32F3N5O6S |
| Molecular Weight | 743.76 |
| AlogP | 6.66 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 109.06 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 6.0 |
| Heavy Atoms | 42.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Casein kinase I epsilon inhibitor | FDA |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Lymphoma, Follicular | 4 | D008224 | FDA |
| Lymphoma, B-Cell, Marginal Zone | 4 | D018442 | FDA |
| Leukemia, Lymphocytic, Chronic, B-Cell | 3 | D015451 | ClinicalTrials |
| Lymphoma, Large B-Cell, Diffuse | 2 | D016403 | ClinicalTrials |
| Polycythemia Vera | 1 | D011087 | ClinicalTrials |
| Pancreatic Neoplasms | 1 | D010190 | ClinicalTrials |
| Rectal Neoplasms | 1 | D012004 | ClinicalTrials |
| Lymphoma, Mantle-Cell | 1 | D020522 | ClinicalTrials |
| Colorectal Neoplasms | 1 | D015179 | ClinicalTrials |
| Lymphoma, T-Cell, Peripheral | 1 | D016411 | ClinicalTrials |
| Stomach Neoplasms | 1 | D013274 | ClinicalTrials |
| Esophageal Neoplasms | 1 | D004938 | ClinicalTrials |
| Hodgkin Disease | 1 | D006689 | ClinicalTrials |
| Primary Myelofibrosis | 1 | D055728 | ClinicalTrials |
| Gastrointestinal Stromal Tumors | 1 | D046152 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3989869 |
| FDA SRS | FU8XW5V3FS |
| PubChem | 86707828 |
| SureChEMBL | SCHEMBL15556872 |
CONTENTS