TG100-801

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 1VZO7A0J9S

Structure
InChI Key JMGXJHWTVBGOKG-UHFFFAOYSA-N
Smile Cc1cc(-c2cc(OC(=O)c3ccccc3)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12
InChI
InChI=1S/C33H30ClN5O3/c1-22-19-24(28-21-27(13-14-29(28)34)42-32(40)23-7-3-2-4-8-23)20-30-31(22)36-33(38-37-30)35-25-9-11-26(12-10-25)41-18-17-39-15-5-6-16-39/h2-4,7-14,19-21H,5-6,15-18H2,1H3,(H,35,36,38)

Physicochemical Descriptors

Property Name Value
Molecular Formula C33H30ClN5O3
Molecular Weight 580.09
AlogP 7.09
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 9.0
Polar Surface Area 89.47
Molecular species BASE
Aromatic Rings 5.0
Heavy Atoms 42.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Ephrin type-B receptor 4 inhibitor PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Wet Macular Degeneration 2 D057135 ClinicalTrials
Diabetic Retinopathy 1 D003930 ClinicalTrials
Macular Degeneration 1 D008268 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL403989
DrugBank DB05075
EPA CompTox DTXSID20235791
FDA SRS 1VZO7A0J9S
SureChEMBL SCHEMBL12198196
ZINC ZINC000029136020
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