EVOCALCET

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: E58MLH082P

Structure
InChI Key RZNUIYPHQFXBAN-XLIONFOSSA-N
Smile C[C@@H](N[C@H]1CCN(c2ccc(CC(=O)O)cc2)C1)c1cccc2ccccc12
InChI
InChI=1S/C24H26N2O2/c1-17(22-8-4-6-19-5-2-3-7-23(19)22)25-20-13-14-26(16-20)21-11-9-18(10-12-21)15-24(27)28/h2-12,17,20,25H,13-16H2,1H3,(H,27,28)/t17-,20+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H26N2O2
Molecular Weight 374.48
AlogP 4.4
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 52.57
Molecular species ZWITTERION
Aromatic Rings 3.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
POSITIVE ALLOSTERIC MODULATOR Calcium sensing receptor positive allosteric modulator PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hyperparathyroidism, Secondary 3 D006962 ClinicalTrials
Hyperparathyroidism 1 D006961 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL4297621
DrugBank DB12388
DrugCentral 5307
FDA SRS E58MLH082P
Guide to Pharmacology 9042
PDB H43
PubChem 71242808
SureChEMBL SCHEMBL14668291
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